Who Created Viagra

Viagra sildenafil is one of the most widely-known prescription drug names on the U. Often dubbed "the little blue pill", Viagra sildenafil was the first phosphodiesterase 5 PDE5 inhibitor approved to treat erectile dysfunction ED. ED is a common sexual problem for men and its frequency increases with age.

It is estimated roughly 30 million men in the U. A large U. The discovery that sildenafil could lead to an erection was an unplanned event. The sildenafil compound was originally developed by Pfizer for the treatment of hypertension high blood pressure and angina pectoris chest pain due to heart disease. During the heart clinical trials, researchers discovered that the drug was more effective at inducing erections than treating angina. Pfizer realized ED was an unmet medical need and a major opportunity for financial gain.

In , the FDA approved Viagra, the first oral treatment for erectile dysfunction, under a priority review. Pfizer promoted Viagra and ED awareness via direct-to-consumer DTC advertising, which prompted men to seek medical advice and a prescription from their doctors.

For many men, the stigma and embarrassment of talking to their doctor about ED has declined since the introduction of Viagra and other PDE5 inhibitors. Erectile dysfunction ED , or the inability to achieve and maintain an erect penis for sexual function, can lead to performance anxiety, a negative impact on self-esteem and personal relationships, and even clinical depression.

In a survey published in BMJ , 62 percent of men reported a decline in self esteem, 29 percent reported a negative effect on a relationship, and 21 percent reported that their relationship had ceased due to ED. For many men, the inability to perform adequately during sex directly affects their feelings of masculinity.

Risk factors for ED include underlying health issues such as diabetes, high blood pressure, obesity, high cholesterol, chronic alcohol or drug abuse, certain medications, and injuries, all of which can also contribute to erectile dysfunction ED. Any condition that may restrict blood flow to veins over time, like smoking and normal aging, can lead to ED. Medical conditions like Parkinson's disease or Peyronie's disease scar tissue build-up in the penis may also cause ED. Mental health issues can take their toll, too -- depression or stress can result in loss of libido.

Erection failures may occur repeatedly in men who experience performance anxiety due to ED. Many medications have impotence or sexual dysfunction listed as a side effect.

A medication review should be performed by a health care provider to determine if any prescription drug treatment may be contributing to symptoms.

If you regularly experience sexual function or ED problems, contact your doctor for evaluation and treatment. Viagra works in response to sexual stimulation to increase the blood flow to the penis leading to an erection.

Viagra does not result in an erection without sexual stimulation. When a man is aroused, muscles in the penis relax to allow this greater blood flow. Viagra helps to elevate the levels of a substance cyclic guanosine monophosphate, or cGMP that causes the tissues to relax, leads to an inflow of blood, and causes an erection with sexual stimulation.

However, knowing that one can perform better in bed may indirectly boost libido. Several of these agents are now available generically, too, which can help in the wallet. Viagra sildenafil is taken by mouth usually as a 25 or 50 milligram mg tablet one hour before sexual activity. However, Viagra may be taken within a range of one-half hour to four hours before sex.

The dose may be adjusted based on doctor recommendations, but it should not exceed mg per dose and should not be taken more than once per day. A physician will prescribe your specific dose. Have your pharmacist check for drug interactions , too. Men who use nitrates such as nitroglycerin or isosorbide should never use Viagra or other PDE5 inhibitors Cialis, Levitra, Stenda, or Staxyn due to severe, possibly fatal hypotension low blood pressure.

In general, the most common side effects with PDE5 inhibitors like Viagra are mild and short-lived. Side effects may include:. Report a sudden hearing or vision loss to your healthcare provider immediately.

An erection lasting more then 4 hours priapism is a rare event, but if it occurs get emergency treatment. Be sure to review Viagra drug interactions and precautions with your healthcare provider prior to use. Your dose of Viagra may need to be adjusted based on other drugs you may be taking. The simplicity of taking an oral tablet for erectile dysfunction has revolutionized treatment.

However, PDE5 inhibitors may not work in about 30 percent of men. It is important for men to know that there are other options available for ED. These solutions were used prior to Viagra, and are still available today:. These options may be useful for some; however, for many men they can be complicated, painful, and more expensive. Be sure to talk to your doctor about all options.

Recently, a large-scale clinical trial found that canakinumab Ilaris a drug used to treat one form of arthritis made by Novartis, could also be used to treat heart disease after researchers understood that inflammation may play a role in the latter. Before that, in , the compound bimatoprost Lumigen , which was made by Allergan to treat high eye pressure, was approved to enhance eyelash growth under the name Latisse after people taking it kept reporting the glamorous side effect.

And the compound finasteride was first used in the drug Proscar, made by Merck, to treat swollen prostates, but was later approved to treat baldness under the name Propecia when patients reported they noticed hair changes after taking the drug. Some people taking finasteride have reported some fairly horrific side effects , in some cases long-term. In all of these cases, the second application was found after the drug was on the market for a while.

It could improve or even save lives. Over the past decade, Futura have developed a GTN-based gel called Eroxon which appears to be capable of inducing an erection in patients with mild to moderate erectile dysfunction in five to 10 minutes. After investors showed a renewed interest in backing novel treatments for erectile dysfunction, Futura completed a clinical trial of patients last year, and have now embarked on a final phase III trial of 1, patients to be completed by the end of If this succeeds, Eroxon could become available clinically within the next couple of years, although urologists remain cautious.

In the past there have been few options for these people, but over the past five years, the renewed interest in erectile dysfunction has seen research programmes dedicating more time and money to clinical trials of a technology known as shockwave therapy.

Unlike Viagra or Eroxon, this attempts to reverse the problems which cause the dysfunction by passing low-intensity sound waves through erectile tissue.

Scientists are still not entirely sure how or why it works, but so far they think it leads to a form of regeneration of the erectile tissue, promoting the growth of new blood vessels and clearing plaque from existing vessels. However, because there is such a wide spectrum of causes of erectile dysfunction, shockwave therapy is currently only known to work in a subset of these patients, particularly those where the damage has resulted from diabetes or hypertension.

Hatzichristodoulou points out that there remains a need for further data, with a series of trials of shockwave therapy currently going on in Europe and the US. But compared to Viagra or Eroxon, one of the great promises of the treatment is that it would not be needed on a regular basis. Instead, patients could simply undergo maintenance therapy at half-yearly or annual intervals. Most tantalisingly, in attempting to restore the natural function of the penis, it points towards an eventual cure, a hope which may yet be realised in years to come.

Even when Viagra works, one of the problems for people who need to take it indefinitely is that it becomes less effective over the course of months or years. Desperation has pushed many patients towards unscrupulous private clinics around the world, who promise an ultimate cure, offering treatments like shockwaves, stem cell infusions and injections of platelet-rich plasma on an unregulated basis.

But all of these therapies are highly experimental — as an example, shockwave therapy is currently only approved by the US Food and Drug Administration to stimulate wound healing, as scientists are still working on establishing the best doses for efficacy and investigating long-term safety.

who created viagra

Nicholas Terrett is named in the British patent for sildenafil citrate, or Viagra, as a heart medication. Terrett is often considered the father of Viagra, according to ViagraBox. First 'ED' drug out in 10 years Searching for 'Himalayan Viagra' Early s: Pfizer completes several early trials of sildenafil citrate that provide little hope for its use as a heart disease treatment. But volunteers in the clinical trials are reporting increased erections several days after taking a dose of the drug, according to researcher Ian Osterloh.

Testosterone: 'Viagra for the boardroom'. It could improve or even save lives. The more data, the better. While drug discovery does involve a lot of research and development, it also involves serendipity and spotting unusual details. This same kind of luck and vigilance could uncover new uses for existing treatments.

Retrieved 1 July Pharmacological Reviews. Retrieved 20 August Br J Clin Pharmacol. Org Process Res Dev. Archived from the original on 26 September Retrieved 6 August Our clinicians regularly offer patients the opportunity to take part in trials of new drugs and treatments.

Morriston Hospital in Swansea, was the first in the world to trial Viagra! Bioorg Med Chem Lett. Nature Reviews. Drug Discovery. Drug Repurposing and Repositioning: Workshop Summary. National Academies Press. Drug Discov. Daily Record. Retrieved 30 April Health Aff Millwood.

Haymarket Media. Archived from the original on 3 January The New York Times. Retrieved 19 December BBC News. Retrieved 5 April The Independent. Retrieved 6 May Retrieved 10 December Retrieved 6 December Hindustan Times.

New Delhi. Retrieved 10 August The Economic Times. Archived from the original on 19 November Retrieved 26 December Retrieved 10 January Retrieved 25 October Retrieved 25 March The Guardian. Retrieved 13 June London: Telegraph Media Group Limited. Archived from the original on 22 August Thomson Reuters.

Archived from the original on 25 June Pharmaceutical Journal. Retrieved 8 October Consumer Reports. Retrieved 4 May Zacks Equity Research. Retrieved 5 October Retrieved 1 April Stikeman Elliott.

Retrieved 14 November Ratiopharm Inc. Share Flipboard Email. Mary Bellis. Inventions Expert. Mary Bellis covered inventions and inventors for ThoughtCo for 18 years. She is known for her independent films and documentaries, including one about Alexander Graham Bell. Updated April 13, ThoughtCo uses cookies to provide you with a great user experience.

Viagra Makes History

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History of Viagra and how it was discovered by accident

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Sildenafil, sold as the brand name Viagra among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is. Learn more about the long strange history of Viagra as the little blue pill turns 20 in including generic viagra, pricing, usage, and where. Famously, Viagra was never intended solely as a boner-boosting drug. Originally developed in as "UK" by Pfizer scientists Peter.
who created viagra